Abstract Diabetes mellitus (DM), both type 1 and type 2, has been linked to decreased performance across a number of cognitive function categories, with more recent studies emphasizing the contribution of DM mediated dementia
A small trial in mixed hepatitis patients demonstrated that 480 mg silibinin daily for 7 days could significantly reduce aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltranspeptidase (GGT), and bilirubin, all markers of liver dysfunction (Buzzelli 1993)
Hepatoprotective activity of Sonchus asper in paracetamol-induced hepatic damage in rabbits
Additionally, GLP-1 RAs modulate the hypothalamus (the region in the brain that controls appetite) to regulate hunger, slow gastric emptying, and regulate gut hormones such as leptin (a hormone that helps regulate body weight on a long-term basis)